![]() The preoperative serum AFP level was a sensitive prognostic biomarker for DFS and OS. ConclusionĬNGs at 20q11.21-13.12 happened frequently in HAS and tended to be related to more adverse biobehaviour. The survival analysis showed that a preoperative serum AFP level ≥ 500 ng/ml was significantly associated with poorer OS ( p = 0.007) and tended to be associated with poorer DFS ( p = 0.05). Pathway enrichment analysis revealed that the HIF-1 signalling pathway and signalling pathways regulating stem cell pluripotency were specifically enriched in HAS. This CNG tended to be related to more adverse biobehaviour, including poorer differentiation, greater vascular and nerve invasion, and greater liver metastasis. Copy number gains (CNGs) at 20q11.21-13.12 occurred frequently in HAS, nearly 50% of HAS tumours harboured at least one gene with a CNG at 20q11.21-13.12. Additionally, CEBPA, RPTOR, WISP3, MARK1, and CD3EAP were identified as genes with high-frequency mutations in HAS (10–20%). The most frequently mutated gene in both HAS and CGC was TP53, with a mutation rate of 30%. Prognostic factors for overall survival (OS) and disease-free survival (DFS) were analysed with the Kaplan–Meier method. Based on a panel of 483 cancer-related genes, targeted sequencing of 24 HAS and 22 clinical parameter-matched common gastric cancer (CGC) samples was performed. Methodsįorty-two patients with HAS who received gastrectomy were enrolled in this study. The aim of this study is to elucidate the clinicopathological and molecular characteristics of HAS. ![]() ![]() Hepatoid adenocarcinoma of the stomach (HAS) is characterized by histological resemblance to hepatocellular carcinoma and a poor prognosis. ![]()
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